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Week 2: Production Refinement

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The team moved forward with the proposed magnetic field induced drug delivery system, brainstorming ideas for the synthesis of the alginate vehicle. Based on feasibility estimates, it was decided that the concept should be first demonstrated on a millimeter scale. This would allow for easy visual observation of the alginate vehicle and encapsulated substances and give the team more control over the synthesis process. The decision to demonstrate on the macroscale was also driven greatly by the lack of access to equipment required to fabricate and observe hydrogels on a more realistic, 2-3 micron scale. Earlier in the week, the group also ordered required materials for the project, including culinary sodium alginate, shown in Figures 1 and 2, and 28 gauge needles for alginate injection. Although the final product will undoubtedly require high purity alginate, food grade alginate should suffice for the proof of concept. The team also scoured Drexel's chemistry labs for calci...

Week 1: Brainstorming and Idea Development

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After the first lab, the group brainstormed and produced the following ideas: Control the release of alginate (integrated with iron/medicine) using magnetic fields and variations of the density of alginate A long, flexible tube made of alginate that would be inserted into the patient’s esophagus and help prevent heartburn Topical applications - skin cream composed of alginate that keeps the skin moisturized Utilizing alginates metal-binding properties to extract unwanted metal ions from the blood A medicine that is stored within alginate gel, so that when a region of the body receives blunt physical force, the gel capsules in the blood vessel of that region break open and release some sort of steroid or painkiller After some deliberation, the group determined that the first idea had the most potential to be both successful and doable by the group. The working idea is that the alginate capsules are filled with both the medication and iron oxide. Upon agitation from...